West Virginia is well known for its glass manufacturing on a small artisan scale and also a large factory scale. The Museum of American Glass is a non-profit museum that was founded in 1993 with a goal of preserving any component of the glass industry in West Virginia as well as the United States. The Museum of American Glass focuses on the whole history behind glass work in West Virginia and gives insight to the people, factories, and products that made glass such a valuable piece to West Virginia's history. The WVMAG also contains an archive of oral histories from the glass blowers and archives from the American Flint Glass Workers Union, which is one of the oldest unions in the United States. From 1777 until 1795, this site was occupied by a log building used by the Indian Spy Service of the Virginia Melita. Two buildings have succeeded it: The original Bailey House hotel, where the future Stonewall Jackson took the examination for admission to West Point. The building burned in 1877 and was replaced by the current structure build in 1885 by PM Hale and the home of the Lewis County Bank in the first quarter of the 20th century. It is now occupied by the West Virginia Museum of American Glass. The side of the West Virginia Museum of American Glass has a mural which illustrates the community’s rich history in the glass industry. Each piece of glass painted on the side of the building is available to view at the museum. This mural was completed in 2020 by West Virginia artist, Jesse Corlis.

The Louis Bennett Public Library is located within a historic home in Weston, West Virginia. The seventeen-room Victorian mansion was built in 1875 by Jonathan M. Bennett, one of the most prominent politicians and businessmen in Lewis County. His son Louis was also a noted civic leader, serving as Speaker of the House of Delegates and unsuccessfully running for Governor in 1908. Louis' son Louis Jr. became famous as West Virginia's only ace pilot in World War I. He flew over twenty missions and made twelve confirmed kills before dying in 1918. His mother, Sallie Maxwell Bennett, decided to honor her husband and son by donating their house to the Lewis County Commission to operate as a war memorial and library in 1922. Today the home continues to house a library while the property includes a war memorial. The house was added to the National Register of Historic Places in 1978.

Trans-Allegheny Lunatic Asylum (TALA), was a psychiatric facility that operated from 1864-1994 and served patients exhibiting atypical behaviors. Over the years, the institution was also known as West Virginia Hospital for the Insane/Weston State Hospital. The main building, which was constructed from 1858-1881, was designed by Richard Andrews and features an eclectic blending of revival styles. The general layout and furnishing of the hospital was guided by Dr. Thomas Kirkbride, who felt mental health patients needed housing that provided therapeutic features such as many windows for sunlight and access to fresh air. Moreover, this hospital was designed to be self-sustained by those working at the asylum and patients alike; working in the garden would be a positive mental and physical stimulator for the patients. Despite the lofty goals of the institution, it was plagued by overcrowding and underfunding. Conditions quickly deteriorated and by the middle of the twentieth century the environment for patients was deplorable. Experimental therapies and brutal medical procedures exacerbated issues. Due to the shift in mental health care from the asylum to more community-based efforts and because of the overall deterioration of the building, the hospital was closed in the 90’s. Today, a new owner has reopened the hospital, advertising a living historical monument where heritage tours and even haunted ghost tours are offered to the public.