Built sometime between 1880 and 1890, the building at 57 Main Street (currently Ayres Realty and Insurance) is the largest of Milo Miller's Second Empire buildings. H. H. Tousley operated a grocery in the building c. 1910, and following Tousley was William Mullen with his Saranac Supply. Saranac Supply was located on Main Street until about 1921, after which the Mullen store moved to the Colonial Theater Building on Broadway. During the period of America's involvement in World War I, there was a barrel behind the Supply. Anyone buying peaches was asked to put the pits in the barrel. Periodically, the pits were taken away to a processing plant where they were ground to be used in the filters of gas masks. Between 1922 and 1923, the ground floor was made into two storefronts from one, and had the present facade erected. The first occupant of the northern storefront was the Margaret Kelly Dress Shop. In 1925 it became Irving Altman's ladies' apparel store. Altman remained a tenant there until 1932 when he moved to his own building. For part of this period, Flora Pruess operated a children’s-wear store. In the 1950s, flyweight Golden Gloves champion known to all as "Little Joe", opened a tavern. Little Joe's rapidly became the most popular Saranac Lake meeting and drinking place of the 1950s and early 1960s.
Little Joe's, Historic Saranac Lake Local Wiki. Accessed April 7th 2020. https://localwiki.org/hsl/Little_Joe%27s?&redirected_from=48%20main%20street.
Saranac Lake Free Library