Slocum was given the name Maconaquah (Ma-Con-a-Quah), which means Little Bear or Young Bear, and raised in Native American culture. She married Little Turtle in 1790. One source states that he was a Miami chief but another states that this was not the Miami's chief Little Turtle. Maconaquah, however, divorced him because of domestic abuse and moved back with her foster parents. She remarried Shepaconah (She-Pan-Can-Ah), also known as Deaf Man, who later became the Miami's chief. Maconaquah had two daughters with Shepacanah: Kekesequah and Osawsheguah. She also had two sons who died at young ages.
Maconaquah's biological family continued to look for her with no luck; in 1835, however, a fur trader named Colonel George W. Ewing passed through her Native American village and heard of the story of her abduction. When Ewing returned east, he located her family, who went to visit Maconaquah in 1838. Her family wanted her to return to Pennsylvania, but Maconaquah did not want to leave her Native American family after 60 years. Maconaquah did not leave and continued to live with her family until she died of pneumonia on March 9, 1847 at 74 years old. She was originally buried near her second husband's village, but the graves were moved to the Frances Slocum Cemetery in 1965. Construction of the Mississinewa River Dam threatened to flood the location of Shepancanah's village.
Slocum was significant because she was a white woman who lived with Native Americans. Frances was, however, not subject to the Trail of Tears thanks to her brothers. In 1840, the United States government made a treaty that forced Miami Indians to leave their home on the Wabash River in five years. Maconaquah's brothers helped her appeal to Congress. She and her descendants were allowed to reside on a reservation in Indiana.