During the first two months of its opening Saint Agnes had only four patients and four nurses in training. By May of 1899 the hospital grew tremendously to 60 patients who were being treated in the hospital. African Americans traveled from more than three states to seek medical attention from Saint Agnes because hospitals in their area refused to help them because of the color of their skin. Saint Agnes lacked facilities such as updated equipment and operating tables but in 1903 improvements were made such as new facilities, kitchen and a new sterilization room were some of the new renovations.
Saint Agnes received backlash from those who weren't African American because they didn't want to see them succeed and help their own race. Sarah Hunter was funded grants to help keep the hospital up to date and running and in 1909 Saint Agnes underwent new changes to a new hospital on the Campus of Saint Augustine University. Although Saint Agnes continued to grow, in 1925 the hospital survived a fire followed by a installation of a new elevator in 1926. In 1961 Saint Agnes closed it's doors for good following the opening of Wake Memorial hospital, nearly 58 years later only a shell of the historic building is still standing and is now classified as a Raleigh Historic property.