From MSHPS Nomination: 110 Main Street (1859) faces northwest. This two-story, painted brick commercial building is believed to be one of the oldest commercial structures in Madison Station. The front-gabled roof includes overhanging eaves with decorative brackets. The large upper story windows are six over six sash with true divided lights. The recessed front entrance has two large display windows and a sign band that runs the width of the entrance.
The building now houses Madison Station Antiques.