The building was commissioned by Myron C. and Elizabeth Bonnell Wick and named in memory of their daughter, Helen, who died previously at the age of four. A dedication in honor of young Helen is inscribed into one of the two fireplaces in the chapel. The Wick family was very influential in the early days of Youngstown, Myron Wick was vice president of the First National Bank which occupied the now metropolitan tower. Myron was also an originator of the Ohio Steel Company. Elizabeth Wick was the daughter of William Bonnell, co-founder of the influential Brown-Bonnell Iron & Steel Co.
The Wick family also had a significance to the First Presbyterian church in the area. Reverend William Wick held the first Presbyterian service in 1799 in the Youngstown area. The Helen Chapel became a historic location in 1986 and continues to serve the community of Youngstown.