Unfortunately, Guthrie experienced tragic personal losses growing up, which influenced his songwriting. His sister, Clara, died in a fire that burned down the family house and his mother was placed in an insane asylum for Huntington's Disease when Guthrie was a young teenager. Additionally, his father ran into serious financial trouble after some of his real estate deals failed, which forced his father to find work in Texas. To earn money, Guthrie started to busk (perform on the streets); this enabled him to develop his musical skills and social views. He married his first wife, Mary Jennings, at the age of 19 in Texas (he moved there to live with his father) and they had three children together.
The Great Depression and the Dust Bowl forced Guthrie to leave his family in 1935 and head west to look for work. He traveled via hitchhiking and riding freight trains, and he would perform as often as he could, usually in homeless and migrant camps. Sometimes performing was the only way he could eat. It was through these experience that Guthrie gained a sense of solidarity for workers' rights and other liberal causes. He also developed a love for the road.
Guthrie's first big break came in 1937 in Los Angeles when he got a job as a radio performer singing Oklahoma (Okie) folk songs with partner Maxine Lefty Lou Crissman. Over time, Guthrie incorporated his populist political and social views into his songs. This earned him increasing fame, especially in the migrant worker community.
He made his way to New York City in 1940 where he met and collaborated with other well-known musicians including Pete Seeger. Guthrie played a key role in pushing folk music as a social force during the early 1940s. As a result, his stature rose significantly around the country. In 1943, he wrote the iconic populist American song This Land is Your Land. Guthrie also married his second wife, Marjorie; they had four children together.
Towards the end of the 1940s, Guthrie started to exhibit signs of the disease that killed his mother. He decided to go on the road and traveled to California again, where he met and married his third wife, Anneke (they had a daughter, his eighth child). The disease became worse by the end of the 1950s and Guthrie had to be hospitalized for the rest of his life. He passed away on October 3, 1967.