Architecturally, the district represents a range of styles that weaved in and out of popularity in the next 70 plus years. Italianate homes represent the first popular Milwaukee architectural style, built between 1840 and 1875. Additionally, Greek Revival mansions were constructed during this period, with several notable examples remaining, including a cream city brick home at 1826 North Second Street. Victorian styles dominated the next construction period in the late 1870s and 1880, later giving way to the American Queen Anne architectural style.
After 1915 the neighborhood entered a period of steep decline as the factories and other industries moved away from the area. Many of the homes were either torn down or left in stages of disrepair. Around 700 homes were demolished between 1950 and 1970. In the 1980s a revival movement began to restore the district and again make it a desirable place to live and work. The entire district was granted National Register status in 1982 and efforts began to convert the old factories into attractive apartments and lofts. The former Schlitz brewery was torn down and a park erected in its place (Schlitz Park). Lakefront Brewery opened in the 1990s, once again bringing the brewing industry to Brewer's Hill. Today the neighborhood is bustling and vibrant, trendy and attractive.