Lescaze believed that the design of a home or building could influence the well-being of its residents. Consequently, he purchased the brownstone on E. 48th Street which was built before the Civil War and redesigned it to be more suitable for the modern age. He eliminated ornamentation and created a flat, unadorned exterior with a sleek, curved entryway.
The building is also noteworthy for the use of glass blocks. Though they are widely used now, at the time, they were a novel addition on an American structure. Lascaze had seen them used in Europe and he employed them for skylights as well as for a significant part of the facade. Lascaze used the blocks because they were energy efficient and allowed natural light into the building. The architect had a particular interest in keeping energy costs low, as the home was also the first in the city to have central air conditioning.
The home, which is listed on the National Register of Historic Places and is a New York City Landmark, was put on the market in 2018 for $4.95 million.