In addition to being a great representation of architectural style from the period, the Wells-Schaff House is tied closely to the Wells family. Charles Wells, the family patriarch, was both the founder of the town and served from 1789 to 1810 as the representative for Northwestern Virginia in Congress. Wells settled in this area in 1800, opening a tavern and operating a farm. His son, Eli Wells, constructed this home in 1832. The younger Wells chose this site for the home in an effort to prevent damage from the Ohio River in case of floods.
Besides being a family home, the Wells-Schaff building also served as an office for the Carter Oil Company and as a clubhouse for the local Sitersville Country Club. The home was owned by members of the Wells family from its construction until 1984 when it became the property of Morton Schaff. The property was added to the National Register of Historic Places in 1985.