While operating as a store, the Pendergrass Building had a wide variety of items for sale. The store was known to sell grocery staples, dry goods, notions, school supplies, and other necessities of everyday life in early 20th century Macon County. Many of these examples are among the artifact holdings of the Museum, and are exhibited on a rotating basis in Museum displays. The store was also known as a community gathering place, with lively checker games happening daily on the street outside in the summer and by the wood stove in the winter. It also served as a wedding parlor for many of the couples who were married by the Rev. Pendergrass.
In addition to operating the Museum, the Historical Society publishes a quarterly newsletter, Macon County Echoes, as well as books on county history and genealogy. Additionally, it offers educational and entertaining programs for all ages, promotes historical and heritage preservation, and pursues historical and genealogical research, encouraging others to do research of their own. The photographic and family history collections at the museum are open to the public for research.