In 1884, barrel production and distribution had increased to nearly twenty thousand units which helped to keep Cherokee Brewing competitive. By 1885, one of the signature beers from Cherokee had gained a gold medal for best beer at a regional fair. In the late 1880s, however, Cherokee Brewing would meet a fate similar to many of the other smaller brewing operations when it was swallowed up by the St. Louis Brewing Association. The St. Louis Brewing Association (SLBA) had been buying up smaller breweries in the region to form a conglomerate brewery that would be large enough to compete with larger nationwide breweries and Cherokee was its latest purchase. The SLBA, however, chose to close the Cherokee brewing company in 1899.
Renewed interest in the building itself began in the 1960s when brewing cave aficionados attempted to get a closer look at the old Cherokee Brewing caves, but it had been assumed that the caves were inaccessible. By the late 2000s, the main Cherokee Brewing building had been almost completely abandoned for nearly fifty years when Stuart Keating and several others took an interest in using the old building as a microbrewery and pub. The result of their efforts was Earthbound Beer which began operation in 2014. Earthbound Beer strives to craft beer from unique and, sometimes, archaic recipes. The brewers offer ticketed tours of the old Cherokee Brewing caves which are used by Earthbound today.