In addition to special events held throughout the year, the building is home to the Portland High School basketball team, the Maine Red Claws, and the Maine Roller Derby team. The roller derby team has had the Exposition Building since 2009 and have hosted teams from Ohio, New Jersey, New York, New Hampshire, Rhode Island, Massachusetts, and Connecticut. The Maine Red Claws date back to 2008, when a group of local business owners came together to sign a deal to bring an NBA development league to Portland, Maine. In 2009, the Maine Red Claws began the 2009-2010 season at the Portland Exposition Building.
Some notable figures that have been featured at the Exposition Building include Babe Ruth, John F. Kennedy, James Brown, Dolly Parton, Arnold Palmer, Beach Boys, and many more. There are over 270 events held inside the Portland Exposition Building each year that bring in a total of 600,000 people. These events include basketball, track, trade shows, weddings, conventions, banquets, business meetings, ski shows, and community events.