During the War of 1812 (1812-1815), Native American forces besieged the fort from September 5-12. Despite their best efforts, they failed to capture the fort and retreated on the 12th. That same day, Territorial Governor William Henry Harrison, who would become the 9th President of the United States, arrived with a large relief force and officially ending the siege. The fort remained garrisoned until 1819 as it was no longer needed.
Historic Fort Wayne was originally established in 1964 and opened the site in 1976. After disbanding in 1989, then it reformed again, this time as a volunteer organization in 2004.