The sense of division within the border region of the war is often understated. Union forces occupied Guyandotte, just over 5 miles from Barboursville, in the days preceding the engagement in due to local civil unrest involving seizure of a steamboat. Upon occupation of the Union forces, many citizens took an oath of loyalty to the union, where only days prior many had celebrated delivery of the news that their state of Virginia had seceded from the Union . It is even recalled by some sources that a former local of Guyandotte, Mrs. Caroline White, returned to the area presenting union colors upon her arrival so as to celebrate the now Union controlled town .
After the steamboat seizure near May 25th, former politician Albert Jenkins, sensing an impending conflict, returned to the Barboursville area to begin training a division of Confederate forces to defend Barboursville . On July 13, 1861, citizens of Barboursville and men from Wayne, Lincoln, and Cabell counties gathered on a prominent hill in town. They were commanded by Col. Ferguson of the Jenkins Border Rangers, with additional strength from Capt. James Corn, and the Sandy Rangers. Approximately 600 troops total in strength. Fortifications were made on the hill hence the nickname Fortification Hill. They faced the 2nd KY Infantry under Col. Woodruff.
On July 14-15, Col. Woodruff and the 2nd KY Inf. advanced on Barboursville. After exchanging a few volleys the over-confident but poorly trained and ill-armed Confederate forces and militia were driven from both the hill and town via a wooden covered bridge nearby. Reports from the defeated Rebels stated that the defenders of the Hill, when seeing the bayonets of the Union's rifles, had feared that the Union had started to shoot knives at us. This image had frightened the Rebels, causing them to retreat. James Reynolds of Milton (militia) was killed and a reported 5 wounded. Union forces suffered 5 killed 18 wounded. The victors then secured the town. Days later, the same forces clashed in the lower Kanawha near Scary Creek. Later that year in November, Jenkins Rangers sought revenge by ambushing a Union force camped in the port town of Guyandotte near modern-day Huntington and drove the Union out. The Union forces returned and burned about 2/3 of the town.
On September 8, 1862, Barboursville suffered another minor battle when the previous defenders, Jenkins Rangers (Jenkins was a Cabell local and VA Politician with a plantation nearby) attacked the Ohio Cavalry encamped in the town. The fighting took place along Main Street near modern-day Nancy Cartmill Gardens, interrupting church services. One Union soldier was killed. The battle ended in a draw, with both forces leaving the battle area, Confederate forces were able to maintain a hold on Barboursville. With the town secured in CSA hands, Jenkin's Rangers were able to then invade/raid into parts of Ohio. The Northwest counties of VA voted and eventually left Virginia and rejoined the Union on June 20th, 1863, becoming the 35th state.