An interesting fact about The Knott House is also the area in which it is located in Tallahassee. Two other famous historical housings are located just a block away from the house and they share history due to being in the same area. Not only are they neighbors with history behind them, it also gives the history of the residence that own the homes. Another resident has shared the history of The Knott House and his family was neighbors of the house itself. Back in 1883 Dr. George Betton was a prominent local physician that had acquired the house where he had used it to maintain an office for himself. However, the Betton residence, those of one of the two houses near The Knott House, was in the neighbor house on 133 N. Gadsden and another residence lived in the other house on 125 N. Gadsden.