The Old Natchez Trace was first used by foraging bison, and then Native Americans. Later travelers included European settlers, Kaintucks (who were mostly from Kentucky), slave traders, explorers, and soldiers. Many trading posts were active along the way. There are so many places to eat, shop, and visit. Many of them are listed on the Clio. The Natchez Trace was a major trade route until the coming of the steamboat and the ability to transport goods and services along the Mississippi River became much easier. But locals continued to use it, and it was later declared a national park. The Old Natchez Trace reached its peak of usage between 1785 to 1820.
The Old Trace went through Choctaw and Chickasaw lands. There are also mounds that were created by Native Americans over the course of more than 2,000 years, especially in Mississippi. One of these is Emerald Mound, the largest along the Natchez Trace Parkway. Covering eight acres and 70-feet-tall at its highest point, it was occupied until 1600.;