The Republican Army changed hands to José Álvarez de Toledo y Dubois after Augustus Magee died, and General Gutierrez gave control of the army to Toledo y Dubois. When word reached the San Antonio where the Republican Army was camped, that the Spanish Royal army would attack soon, they vacated San Antonio fearing a siege would bring death to the Republican Armies families. They marched down to the Medina River and attempted to set an ambush for the larger Spanish Army. Cavalry Scouts from the Spanish Army were attacked by the Republican army and fled back to General Arredondo. Believing they had caught the main Spanish Royal Army, the Republican Army gave chase. Their cannons and wheeled guns were quickly mired in the sand and rendered useless for the battle when they came upon the main forces of the Royal Army who had been waiting for the Republicans to fatigue themselves moving the guns. The last part of the battle was quick and bloody. Of the 1,400 Republicans, less than 100 were left alive as Arredondo ordered the summary execution of the militia members.
General Arredondo only lost 55 men in this battle and afterword the Spanish Royalist Army would attack San Antonio anyway for aiding rebels against the Spanish Government. Though this battle was lost, it would spur the remaining Tejanos into fighting against Spain and Mexico’s independence being recognized eight years later on August 24, 1821. Many of the Americans, Mexicans and Tejanos, would later fight again for the Independence of Texas against Santa Anna who was at this battle serving under General Arredondo.