African-Americans were also often excluded from downtown hotels and venues. Segregation even applied to the famous entertainers who performed in the city, like Nat King Cole and Sammy Davis, Jr. From the early 1940s through the 1950s, Genevieve Harrison's house on F Street welcomed African-American guests, including the entertainers who were prohibited from staying at the venues where they performers.
Harrison's Guest House was one of several guest houses on the city's west side which catered to African-American guests. Harrison's hospitality did not mean she wasn't a shrewd businesswoman, however. The rates that she and other guest house owners in the west side charged were considered exorbitant compared to the rates at downtown hotels.
Genevieve Harrison operated the guest house until her death in 1957. At that point, her sister, Agatha, began operating it and continued to do so until at least 1960. By that point, segregation was declining and there was less demand for guest houses that catered solely to African-American travelers.
The Harrison Guest House was added to the National Register of Historic Places in 2016. The home is available for tours and there are currently plans to turn it into a museum.