In early adulthood, Hopper worked as an illustrator, a job he disliked, and as a freelance artist. He made three trips to Paris to immerse himself in the city's art scene. He experimented with the use of different colors and styles. It was only in 1913 at the Armory Show that Hopper sold his first painting.
Hopper gradually became successful in the 1920s. He married Josephine Nivison, also a painter, who spent much of the rest of her life managing Hopper's interviews and work. They lived in Manhattan and spent summers on Cape Cod.
Although Edward Hopper did not live in the Nyack home again, but he retained ownership of the property for the remainder of his life. His sister Marion lived in the house until her death in 1965, when the property began to fall into disrepair. It was nearly demolished but was saved by locals and since 1971 has functioned as an art center. There are mementos of Hopper's life in the center, including some of his early sketches and drawings.
The home is listed on the National Register of Historic Places.