Despite the racism that he encountered when he settled there, Clark saw Iowa as a land of opportunity. Clark's uncle had taught him to cut hair and got him an education in hopes that he would one day open his own barbershop. When Clark hopped off a steamship and arrived in Muscatine in 1941, he did just that. During this time, African Americans often were only hired to do low-paying menial labor, Clark challenged the status quo by not only opening his own shop but also by investing in real estate. Clark launched his campaign on civil rights in the later 1940s and brought his fight for equality in Iowa to the Rochester National Colored Convention in 1953.
In 1857, Clark started a campaign to overturn Iowa's Black Codes and was one of the 33 delegates at a black convention held in Muscatine. Delegates there demanded full citizenship and desegregation in schools. Muscatine had a small colored school, but the level of education was poor and Clark wanted his 12 year old daughter to attend a white school where she could get a better education. After his daughter was denied admission to the white school, Clark filed a lawsuit in the district court, asserting that separate does not mean equal. Clark won the lawsuit which resulting in Iowa being one of the first states to integrate public schools. Known as the colored orator of the West, Clark fought to repeal Iowa's black codes, exclusionary laws, and segregation. Clark's fight for equality crossed Iowa's state boundaries as he pursued answers to civil rights issues nationally.
Clark's house was targeted for demolition in the 1970s before historian and preservationist Kent Sissel bought it in 1978 and had it moved 200 feet to its present location. It took Kent Sissel 32 years to get the Alexander Clark House named a national historical landmark and today it sits as a symbol of hope and inspiration.