As the unit approached Simpsonville, they were attacked by 15 Confederate guerillas led by Capt. Dick Taylor. The 5th USCC, carrying muzzle-loaded Enfield infantry rifles were outgunned by the Confederate guerrillas who carried 6-shot revolvers. All but two of the black Union soldiers bringing up the rear were either wounded or killed. In total, 22 Union soldiers were killed--19 while either trying to surrender or after they were disarmed.
The citizens of Simpsonville helped care for the wounded and buried the dead in a mass grave. Regiment Commander Louis Henry Carpenter documented the names of the Confederate guerrilla soldiers and wrote a letter encouraging their prosecution. There is no record that the Confederate soldiers were held accountable.