The city of Corinth was founded by Houston Mitchell and Hamilton Mask in 1854. Known at one point as the Crossroads of the South, the city played an important role in Civil War strategy. The city was located at the crossing of the Memphis & Charleston and the Mobile & Ohio railroads. This railroad junction made Corinth a strategic transportation hub that the Union and Confederacy fought over frequently.
The Museum's permanent exhibits explore the area's Native American heritage, the railroad industry, the pivotal role the city played during Civil War, aviation, and daily life in the city during the 19th and 20th centuries. Numerous items are on display including Native American artifacts, Civil War relics, fossils, and railroad-related items. There is also a large Coca-Cola collection on loan. The Corinth Coca-Cola Bottling Works features items such as old-fashioned drink machines. A photograph collection and research library, known as the Margaret Greene Rogers Library, are also housed in the depot. Just outside the building is an old red caboose that is open during the museum's regular hours, which visitors can enter. There is also a canon on display that was used in the Battle of Shiloh.