Pardee built the home on 11th Street in 1868-1869. Following the elder Pardee's death, the home passed to his son, George Pardee. George Pardee became a physician like his father, and followed him into politics as well. Pardee served one term as mayor of Oakland and was elected governor of California in 1902. Pardee is remembered as California's earthquake governor because of his leadership in the aftermath of the 1906 earthquake; he traveled back to Oakland from the governor's mansion, and worked twenty-four hour days personally overseeing the recovery effort.
Following the death of George Pardee, the home became the property of two of his daughters, Madeline and Helen. They lived in the home until they died in 1980 and 1981, respectively. Now a museum, the Pardee home remains much as it was when the Pardee sisters died. George Pardee's wife, Helen, collected items from around the world, and most of them are still on display in the home, as well as the original furnishings.
The Pardee Home was added to the National Register of Historic Places in 1976.