Designed by local architect John Minor Botts Lewis, the hospital was built as a three-story structure in the Colonial Revival Style. After only four years, renovations were made in 1916. In 1932, a two-story addition was constructed on the west side of the building. But the most extensive work was done in 1939 with a nearly complete remodeling. The rear building was demolished and replaced with a three-story addition, and a third story was added to the 1932 addition. The most radical change was the replacement of the Colonial Revival Style facade with a Neo-Classical facade.
Lynchburg General Hospital would move to a new location in 1956, and the building would be converted into a nursing home, renamed Tinbridge Manor. The nursing home would stay open until the early 1990s. The building was added to the National Register of Historic Places in 1999 under its original name.