The couple moved to Indianapolis where Sarah gained a wide reputation as a poet. In 1855, Nathaniel was appointed consul to Geneva, Switzerland, and Sarah accompanied him to his new post. They remained in Switzerland for three years. During this time Sarah acted as a correspondent for the Cincinnati Commercial. In 1858 they returned to Indianapolis. Nathaniel died a few months after their return. Nathaniel co-founded Indianapolis's first newspaper, the Gazette, and was Indiana State Librarian from 1851 to 1854.
After her first husband's death, Sarah married Addison Reese, a judge. They lived in Missouri for two years, but she found the climate unhealthy and moved back to Indianapolis. She only used the name Reese for business, and continued with the name Bolton for other purposes. She died in Indianapolis in 1893. She was buried in Crown Hill Cemetery.
Bolton was Indiana's foremost female singer for many years. A complete collection of her poetry was published in Indianapolis in 1886. She has been called the Pioneer Poet Laureate of Indiana. She also donated to the State of Indiana 180 acres of land for the building of what was then known as the Indiana Hospital for the Insane. She is commemorated by the Sarah T. Bolton Relief, a 1941 bronze relief in the Indiana Statehouse. Additionally, and is best known for her poem Paddle Your Own Canoe (1850) and as an activist for women's rights where she worked with Robert Dale Owen during Indiana's 1850–1851 constitutional convention to include the recognition of women's property rights.