During the 1870s, former Virginia Agricultural and Mechanical College (VAMC) president Thomas Nelson Conrad (1837-1905), resided in this house. Conrad served as a Confederate spy during the American Civil War. He is notable for being part of an unsuccessful attempt to kidnap President Abraham Lincoln. In 1892, Conrad penned A Confederate Spy: A Story of the Civil War, a memoir detailing his experiences during the conflict. He later revised his autobiography into the 1904 work The Rebel Scout: A Thrilling History of Scouting Life in the Southern Army. During his tenure at VAMC, the college switched from semesters to the quarter system and the school's farm became financially successful for the first time.
Walter Price and Lucie Price purchased the house in 1900. Nelson Price was born in the house and married Jeanne Wainwright Price. The couple lived in the home until they died in the 1980s. Following Nelson Price's death in 1985, the historic building was subsequently donated to the Town of Blacksburg. His iris garden is still maintained for residents to enjoy.
Since 2009, the Price House has served as the home of Seek Education, Explore DiScover (SEEDS), a non-profit organization dedicated to creating a discovery-oriented learning environment. SEEDS runs and finances the nature center in cooperation with the Town of Blacksburg Parks and Recreation and the Virgina Tech Department of Biological Sciences Outreach Program. The organization runs week-long day camps and programs during the summer to promote interest in the region's ecology and culture.