Although the site is popular with tourists, many schools and educational organizations have incorporated the museum into their curriculum. College-style classrooms inside of the museum can be reserved for meetings, classes, or studio space. The Museum School Programs serve 5,000 students annually, teaching art appreciation, western history, and natural sciences. The program serves students K-12 within the Jackson/Teton area with no admission charge. Furthering their support of learning, the museum offers two highly competitive internship programs. The Education Internship offers a $7,200 stipend for a 12 week internship for a graduate student interested in museum education. The Curatorial Internship also offers a $7,200 stipend for a 12-week program for a graduate student working towards a museum or art related field.
The museum's mission is to collect, display, interpret, and preserve the highest quality North American wildlife art, supplemented by wildlife art found throughout the world. There are many different exhibitions and collections displayed. There are around 5,000 cataloged items in this museum collection. The museum has twelve permanent exhibit galleries and opens one or two temporary exhibits each year. The temporary gallery is usually themed around a topic, time period, or artistic style. These exhibits display items in print, paint, sculpture, ceramics, and even ancient artifacts. One of the most striking permanent pieces is Robert Bateman's painting Chief, dedicated to the American Bison.
The Sculpture Trail is a free outdoor collection of artworks which currently stretches 3/4 of a mile around the museum. The trail is ongoing, therefore works will continue to be added as they are completed. Currently, the trail includes the works of Sandy Scott, Dan Ostermiller, Richard Loffler, and Bart Walter.
Every year, the National Museum of Wildlife Art hosts the Western Visions fundraiser, auctioning the artworks to help fund expansion. The 2017 event will be the museum's 30th annual fundraiser. It is a signature event in the Jackson Hole Fall Arts Festival.