Until the early 1900s, the area was farmland, but as Indianapolis began to expand to the north, a bridge was built over Fall Creek which connected the area to downtown businesses. When automobile ownership became common, the newly-developed suburban neighborhood offered upper-class families an escape from the noise of downtown, and Meridian Park soon became one of the most fashionable districts in Indianapolis.
At one point, the neighborhood was a who's-who of Indianapolis society. Anton Vonnegut, cousin of the future novelist, Kurt, built a stately French revival mansion in the neighborhood. Booth Tarkington made a home at 4270 North Meridian, where he routinely entertained Hollywood celebrities. Pharmaceutical executive Josiah Lilly, actress Frances Farmer, and numerous state-level politicians have called Meridian Park home.
While some families were displaced by the construction of the I-65 entry ramp on 30th Street, the neighborhood has never fallen into decline as have some communities in the city. It remains one of the city's finest neighborhoods, with a mixture of life-long residents as well as newcomers.
Meridian Park was added to the National Register of Historic Places in 1990.