At the time of its construction, the library's fireproofing and facilities were considered very advanced for the time. It is also unique in that the building was designed to look like an open book from the air, with the dome serving as the spine of the book. The first floor of the building contains the entrance hall, offices, and reading rooms. Beyond the entrance hall, the stacks are made up of five floors, with glass ceilings to allow light to filter down to each floor.
Situated at the intersection of North Braddock Street and West Picadilly Street, the Handley Regional Library dominates the heavily traveled intersection with both its size and unique style as compared to the neighboring structures. The building is still owned and maintained by the Handley Board of Trustees and was added to the National Register of Historic Places in 1969. A full restoration was performed in 1999 as part of a preservation effort, which earned the architect, Dennis Kowel, the Lucille Lozier Award, presented by Preservation of Winchester, Inc.