Successful early campaigns of the Woman's Club of Huntington were Clean Up Week and Swat The Fly in 1915, where the club cleaned up the city and hauled the trash to the incinerator and hundreds of flies were eliminated in the result. The club flourished in the 1920s, and the need for a clubhouse was justified. Local Huntington bankers would not grant a loan to the women, but still, they persevered. Three women from the Huntington chapter took a Chesapeake and Ohio train to Richmond Virginia and came back successfully with a $50,000 loan. The exact cost of the land and the house was $50,000, and $5,000 for the furniture. The first cornerstone of the clubhouse for the Woman's Club of Huntington was laid in November of 1929.
The Woman’s Club of Huntington has had the following locations as its homes: the Prichard house on the corner of 11th St. and 6th Ave, the North Parlor of Old Main on the campus of the former Marshall College, The Parish House of Trinity Episcopal Church, Ballrooms of the Hotel Frederick, The Prichard Hotel, and the clubhouse at 1201 Huntington Ave, which was sold in 2000. The Renaissance Center and currently The Guyan Golf and Country Club are where current meetings take place. The building at 1201 Huntington Avenue will always be known as the Woman’s Club of Huntington.