The Spanish hoped the mission would not only facilitate trade, but also assimilate area tribes through the teaching of Christianity and conversion to the ways and valves of the Europeans. In addition to religious and military concerns, the Spanish hoped the Native tribes of this region would grow crops and raise cattle. However, the mission suffered from inadequate food supply and many Natives abandoned the mission.
In 1794, Spanish officials moved that mission to Mosquitos Creek due following a raid by Karankawa Chief Fresada Pinta. The new site was more suitable, but conflict with Pinta and other Native leaders continued. Before long, most of the Natives once again abandoned the mission. Officials relocated their mission a final time to this location in the winter of 1794-5. Unfortunately for the missionaries and their few Native supporters, this mission was in territory claimed by the Comanche-a powerful tribal alliance that controlled large sections of Texas through the 1830s.
Despite the occasional attacks by the Commanche and others, the mission population grew to 224 residents by 1804. The mission continued on, even after the Spanish granted Mexico its independence in 1821. However, internal conflicts between Native Americans-some of whom arrived at this mission following the closure of other missions-led to a decrease in population throughout the 1820s. By 1829, only two dozen Native Americans lived at the mission. In 1830, and the Mexican government decided to abandon the mission.