By 1811, there was growing discomfort with the Spanish rule. When Juan Bautista de Las Casas decided to seize power, he enlisted from the Quartel barracks of La Villita to power his coup. Under Casas direction, revolutionaries successfully arrested Gov. Salcedo and Lt. Col. Herrara and removed them from power for a total of 39 days. However, Casas did not turn out to be the most popular man, and some revolutionaries, disgruntled with his short rule, returned to the royalists, who quickly defeated him. It would take another decade for Mexicans to gain true independence from Spanish rule in 1821.
The flood in 1819 (along with the growing wealth of some Spanish soldiers) changed the architectural setting of La Villita. Fancier and more permanent homes began to exist alongside the poorer huts of other soldiers' families.
La Villita played a significant role in its later place in Texan history. In 1839, the then-president of Mexico, Antonio Lopez de Santa Anna, sent Martin Perfecto de Cos to investigate Texans near San Antonio, who refused to pay duties. Bringing 300 soldiers with him, General Cos intended to arrest many of the Texan critics of the dictator. Instead, Cos ran into the militias organized by Stephen F. Austin and Edward Burleson. Following the Seige of Bexar, Cos surrendered to the Texan troops at 515 Villita Street.
In the 1840s, German immigrants, followed later by Swiss and French immigrants, brought a European twist to the neighborhood. German, Swiss, and French cultures mixed with the original Indian, Spanish, Mexican, and Anglo cultures, creating a unique village. Unfortunately, in the early 1900s the neighborhood deteriorated significantly, as other places gained popularity in San Antonio.
On October 12, 1939, Mayor Maury Maverick led the city of San Antonio to begin a restoration project of La Villita. The National Youth Administration assisted in the restoration, with over 1,800 youths trained in various types of art and crafts through the project. Except while used as a Red Cross Center during World War II, La Villita has been utilized ever since as center to preserve the unique cultural heritage of San Antonio through art and crafts. In 1972, the twenty-seven buildings of the neighborhood were added to the National Register of Historic Places.