In 1763, Chief Pontiac of the Great Lakes Ottawa led an effort, later known as Pontiac's Uprising, to drive the British away from the Great Lakes and the Wabash Valley. He and his warriors eventually reached Fort Ouiatenton that July and easily captured the fort, as well as Lieutenant Jenkins and a few of his men. They were later released during a prisoner exchange in Detroit. Pontiac's Uprising ended in 1765 when Pontiac and Colonel George Croghan, deputy supervisor of Natives affairs for the British, met at Fort Ouiatenon and signed a peace treaty. The end of Pontiac's Uprising marked the slow end of the fort. It was not regarrisoned and by 1778 it was merely a small trading post with only twelve households. During the Revolutionary War, the fort served as a headquarters for both American and British troops, albeit at varying times. Then, in 1786, after a series of raids on Kentucky settlers by Native American tribes living along the Wabash, the Wea were forced to leave their village. In 1791 the fort was destroyed by order of George Washington, and, as time went on, all remnants of it began to disappear.
In 1930, a replica of the fort's blockhouse was built on the estimated grounds of the original fort due to the efforts of a local physician named Dr. Richard B. Wetherill. During the latter half of the 20th century, several archaeological excavations were done of the site and the location of the original location of the fort was discovered about a mile away from the replica. The blockhouse still stands today as a museum and educational center. The fort is visited by many many visitors annually, especially for school field trips. There is also a large festival held at the fort in the fall called the Feast of the Hunter's Moon, where reenactors portray 18th-century French soldiers and Wea tribe members. The event is a tradition that dates back to the 1700s when the French and the Wea met at the fort every fall.