Bernett Sr. sold half-interest in the hotel to his son, Jr., in 1920; Sr. died in 1924. Also in 1924, the city's leading radio station KREX broadcast music from live musicians, the Armand de Beque dance band, from the hotel's massive ballroom. Bernett Jr. was friends with the heavyweight boxing champion, Jack Dempsey, and was said to have been his first manager. In the next decade, the grandeur and free-flowing spirits of the hotel's Oriental Room defied the economic reversal of the Great Depression, but the St. Regis could not overcome the fate of downtown hotels as post-World War II travelers chose economy hotels near interstate highways.
A short-lived boom time for the hotel's bar took place in the 1950s with the uranium mining industry working nearby. The first-floor rooms that had been designed for travelling salesmen to demonstrate their wares were remodeled to provide more lounge space. Bernett Jr. died in 1960 and the new owners of the hotel were Amos and Roland Raso and A.W. O'Brien. The bar business turned out to be more of a success than the hotel. The hotel closed in 1985 and was nearly demolished in 1986.
The St. Regis Hotel was listed in the National Register of Historic Places in 1992 for its contribution to local commerce and for its Chicago and Italianate architectural styling. By that time period, the building held an active restaurant. In 2010, a fire nearly destroyed the historic building but thanks to the efforts of the local fire department the damage was minimal. The bar, The Feisty Pint, is one of the ground floor occupants now, a craft beer pub and restaurant.