The 21c Museum displays contemporary works from local and national artists. The museum also brings in special temporary exhibits that borrow from the collections of other galleries and museums, allowing residents to see the works of contemporary artists from around the world.
The museum is decentralized, with galleries and works of art located within each of the five former warehouse. As one might imagine, significant renovation was necessary to re-purpose these structures to the needs of a hotel and art museum. However, great effort was taken to make sure that the exterior of each building remains true to the original designs of the buildings. Because of the hotel's mission to rebuild local economies, the chain is frequently found at the top of ratings lists for boutique hotels.