The Calhoun family sold the mine in 1879. It was eventually believed that the ore deposits were depleted until a small pocket was discovered in 1939. This pocket was mined, and the mine has remained quiet ever since. The mine was added to the National Register of Historical Places and named a National Historic Landmark in 1973.
The Calhoun Mine is known historically as a factor in the removal of the Cherokee tribe from their land. The mine was located adjacent to land the Cherokee inhabited. Many calls for their removal resulted from conflicts between the miners and the Cherokee.