The museum exhibits begin with an account of Hernando DeSoto's exploration of what is known as Mississippi today. DeSoto's interactions with the original Native American inhabitants of the land are also discussed. Some other featured exhibits include a working model paddlewheel boat, the parlor of an antebellum mansion, and various items from the Civil War and World Wars I and II. Additionally, exhibits cover the Native American, African American, riverboat, and agricultural history of the area. DeSoto was a predominately African American county from the days of slavery until the 1960s, so the area has a unique African American history.
Alongside the exhibits, the museum offers another piece of history for visitors to enjoy. An original log cabin is present on the museum grounds. Built by the Crumpler family in 1850, the structure is one of the oldest dogtrot style cabins in DeSoto county. The cabin was expanded throughout the years, but what remains at the museum today is the core of the structure. The cabin was lived in until around 1986 and was donated to the museum several years ago.