The Johnston-Meek House was first constructed in 1832 by Henry Clark. It passed through several different owners in the following three decades before being purchased in 1863 by John L. Johnston, part of a prosperous Irish farming family in the area. It is speculated that the home may have been a stop on the Underground Railroad, though this has not been substantiated. The venerable house saw its first major architectural additions after it was purchased by attorney John E. Meeks in 1919. These renovations were designed by local architect Sidney L. Day; the house is believed to be his only surviving residential work in Huntington. In 2017 the property was purchased by the Children's Home Society of West Virginia, which now preserves the site and uses it for office facilities. It was listed on the National Register of Historic Places in 2000.
The earliest known owner of this plot of land was Thomas Scribbling, who acquired the property from the Savage Land Grant. In 1832 Henry Clark purchased the land and that same year built a modest brick home. The house was originally made in the Adamesque style; it was T-shaped and faced the Ohio River. Clark expanded the house in 1838, increasing the size of the first floor and adding a second floor. In 1843 local businessman Sampson Saunders purchased the house. Saunders is most known today in the area for freeing all of his slaves upon his death in 1849 and providing land for them to settle on. There is no evidence that he ever actually lived in the house.
After Saunders’s death the house passed through several owners before it was acquired by Irish immigrant brothers William and John Johnston in 1863. The Johnstons owned a large and prosperous farm that stretched between what is now First Street and Fifth Street West; they produced and shipped a variety of livestock and crops such as apples and grains. Some sources suggest that the Johnstons were abolitionists and operated a stop on the Underground Railroad at the house, but these claims have not been verified.
Years later the house was purchased by Huntington attorney John E. Meeks in 1919. In 1923 he began the most extensive series of renovations to date on the home. Meeks hired local architect Sidney L. Day to design the additions. Day and his architectural firm were notable for designing such structures as the Foster Memorial Building, Highlawn Presbyterian Church, and the Watts-Ritter & Company building. The Johnston-Meek House is believed to be the sole surviving private residence in Huntington designed by Day. The renovations changed the home into a Colonial Revival style house. Additions included multiple new rooms, a brick terrace, and a large, stone fireplace. In 1941 Sidney Day was hired again by the Meeks to design a two-car garage for the home.
The house continued to be occupied by the Meeks family for many decades. In the early 2000s it was purchased by Carlton Bailey and Elizabeth Caldwell, who worked to restore the home and list it on the National Register of Historic Places. It ceased to be a private residence in 2017 when it was acquired by the Children’s Home Society of West Virginia. The Society was established in 1896 as a branch of the National Children’s Home Association. The organization is dedicated to providing homes and foster care services for homeless children across the state. Today the Johnston-Meek House functions as the Society’s Janet Smith Vineyard Forever Families Center for Permanency, a facility that provides additional foster care and adoption services to families in the local area.