The fort guarded the oxcart trails of the later fur trade era, military supply wagon trains, stagecoach routes, and steamboat traffic on the Red River. It also was a supply base for two major gold-seeking expeditions across Dakota into Montana. Fort Abercrombie served as a hub for several major transportation routes through the northern plains.
After the fort was abandoned in 1877, fort buildings were sold and removed from the site. A Works Progress Administration (WPA) project in 1939-1940 reconstructed three blockhouses and the stockade and returned the original military guardhouse to the site. Beginning in the summer of 2001, a project to refurbish major portions of the WPA project and to reinterpret the site was initiated.