The museum displays an historic stagecoach and a 1958 Cessna aircraft. The local uranium mining boom from the 1950s is represented in exhibits.
A temporary gallery exhibit in 2020 is titled Famous, Framed and Folk Art: Eclectic Art from the Museum of the West's Collections. Artworks by Harold Bryant, Alfred Nestler and other prominent local artists are on display, along with folk art carved wagon trains.
The museum's tower, the Sterling T. Smith Education Tower, offers fantastic, 360-degree views of the area. There are exhibits on local geology, archaeology and historic preservation in the tower, too. The second floor of the building houses the Loyd Files Research Library, currently open by appointment only, Tuesday to Friday, 10a-4p. The library specializes in regional natural and cultural history and contains over 3,000 books in the Mesa County Genealogical Society's collection, historical maps, and other materials gathered by the county's Historical Society and the Quahada Chapter of the Colorado Archeological Society. Onsite research at the library is free, unless there are large-scale or commercial requests for research.
The Museum of the West currently charges admission of $7 for adults, $6 for seniors, $4 for children, and $20 for immediate family groups of up to six people. Members get in for free.
Special events are sponsored by the museum throughout the year. The second annual Speakeasy event on May 8, 2020 celebrates the roaring 20s, and encourages one and all to dress in period costumes.
The Museum of the West and the Loyd Files Research Library are part of a group in the region that form the Museums of Western Colorado. The others are the Cross Orchards Historic Site on the outskirts of Grand Junction and the Dinosaur Journey Museum in Fruita. The mission of the museums is to inspire and connect their community by championing the scientific and cultural heritage of the Colorado Plateau.