Walser Sly Greathouse, the executor of Charles' will, established the museum in Frye's name and became the first to manage it's operations. His wife, Ida Kay, became the second director in 1966 after Greathouse had passed away. She ran the museum until her retirement in 1993 and a year later Richard West, a man who had a great deal of experience running museums, was appointed the director. In 2003 West retired and the job was given to historian Midge Bowman. Bowman contributed a great deal to the Frye Art Museum by establishing an archive and research projects. Today, the museum is run by Jo-Anne Birnie Danzker, the former director of Museum Villa Stuck in Munich and the Vancouver Art Gallery in Canada.
Presently, the museum's collections have grown beyond the Frye Founding Collection. The pieces continue to complement the Founding Collection with additional German and other European artwork. Pieces that make up the collection include oil paintings, watercolors, etching, lithograph (a way of printing from a prepared flat stone, metal, or plastic plate with a greasy crayon or tusche drawing that is washed with water, recovered in ink, and applied to a surface1), pastel, pencil, acrylic, charcoal, mezzotint, mixed media, and more. American artist's works have contributed to the collections as well.
The museum offers a variety of guided tours, gallery talks, exhibition lectures, art history lectures and courses, film, music, and exhibition performances. Furthermore, the museum schedules field trips and visits for students of all ages promoting art history education. In fact, education is one of the most important fundamentals at the museum. For example, professional development opportunities are also offered that use hands on lectures, workshops, and film to inspire collective community discussion.
From it's founding the Frye Art Museum, at it's core, has been about a love of art. Charles and Emma were art enthusiasts that have, unknowingly, inspired many who have visited the museum; and those that have lent a hand in it's continued operations and evolvement have only improved upon the initial vision.