As for Nathan, who was the youngest of Daniel's children, he made a living as a trapper, salt maker, farmer, and merchant. He also served in the War of 1812 as a captain in the 1st U.S. Regiment of Dragoons; he would eventually achieve the rank of lieutenant colonel. He played a key role in the negotiations between the Osage Indians that resulted in the Osage Treaty of 1808 (it is also known as the Treaty of Fort Clark), in which the Osage Tribe ceded most of what is now Missouri and northern Arkansas to the United States. Nathan was also a delegate to the Missouri constitutional convention of 1820.
During the following years, he worked as a surveyor for the federal government along the Iowa/Missouri border. In 1832, Nathan would return to military service when he participated in the Black Hawk War; he continued to serve until he retired in 1853. During this time he helped guard the Santa Fe Trail and participated in negotiations with various plains tribes. In 1837, Nathan was forced to sell the home here in Defiance because of a debt he accrued and moved to Greene County. He died in 1857.