His first real work was as an extra on silent films such as The Merry Widow (1925), The Plastic Age (1925), Forbidden Paradise (1924). His first role in a sound picture was as a villain in the film The Painted Desert (1931). He was a costar to Joan Crawford in Dance, Fools, Dance (1931). In his last supporting role in his career, he played as a gangster in the movie A Free Soul (1931). In 1939, his biggest hit was his role in Gone with the Wind in which he was nominated for a best actor Oscar.
In 1942, Gable joined the U.S. Air Force. He was promoted to major before the end of WW2 before he was relieved of active duty. He continued making films after WW2, but took a time of rest before he continued filming. He had two children, a girl named Judy and a son named John. Gable died on November 16, 1960 ten days after he had a heart attack at the age of 59.