The Mexic-Arte Museum's permanent collection includes some 1,500 works of art ranging from paintings and sculptures to masks and photographs. These include the Contemporary Latino Artists Collection, the Serie Print Project Archive, the Ernest F. de Soto Collection, and the Taller de Grafica Popular Collection. The majority of permanent items are ceremonial and decorative dance masks, important components of many Mexican cultural activities. There is also a library containing over 5,000 books dating back to the 19th century. In addition to the permanent collection, the Museum also hosts a number of temporary art exhibits year-round.
The Mexic-Art Museum has presented a variety of educational programs and social events throughout the years to share Mexican and Latin American culture. These include an annual Day of the Dead festival and parade, a Catrina Ball, poetry nights, and a Screen It! program that teaches students screen printing.