The site, design, and construction of the clubhouse were all donated to the La Jolla Woman's Club by philanthropist and club member Ellen Browning Scripps. The project cost a total of $40,000. The building is a prime example of Irving Gill's modern style, exemplified by simple geometrical shapes, and generous use of arches and columnns, with a minimum of ornamentation. This style has been described as shaved Spanish, as it owes much to the colonial Spanish architecture of southern California - and in particular the California missions - with an emphasis on flat rooflines, and lack of frills. The building also was a product of Gill's experimentation with the concrete tilt-wall construction method, in which concrete slabs were poured in place onto a large table positioned at a fifteen-degree angle. After it was set, the wall was lifted into place, and windows fitted into it. The interior of the building also showcases Gill's interest in sanitation: there are no baseboards, mouldings, or other design details, as Gill believed that these features trapped dust and dirt. The La Jolla Woman's Club has been called one of Gill's most successful works.
The building was added to the National Register of Historic Places in 1974, and is one of several notable Gill-designed buildings in La Jolla, along with The Bishop's School and the La Jolla Recreation Center. The clubhouse is open to visitors on Saturdays from 9:00 am to noon.