Descendants of owners Jacob Epple and August V. Kuehn include their great-grandchildren Jann Kuehn Adams, Charles Barnes, and William Marshall. Charlotte Kuehn is the only member of the Kuehn family who still bears the last name. Her grandfather, August Kuehn, was the president of the company. Kuehn died in 1913 and was succeeded as company president by Epple. Epple ran the company until it closed in 1924 due to the onset of Prohibition in 1919.
The Marietta Brewery continued as a soft drink bottling plant through the end of Prohibition in the early 1930s. It was demolished in the 1940s, and a service station stood at the Second Street location until it was torn down. Some remains of the original brewery can still be seen in the basement of the first settlement building where a stone-arched former brewery storage facility has been turned into a physical therapy room. The alley that runs behind the medical facility, off St. Clair Street between Front and Second Streets, continues to bear the name Brewery Lane.
Over the years, the Marietta Brewery has been through many owners. In October of 2009, the owner, Kevin Laughery, almost lost the liquor license for the popular brewery. Then, he chose to sell it to Dave Broughton, who bought it at a local auction. Only a few months later, Tony and Dana Styer bought the brewery. They continue to run the flourishing business today.