Carter Glass held a prominent position during the early to mid 20th century. At the time he bought the house, he was one of Virginia's Representatives to the House of Representatives (1902-1918). He became the Secretary of the Treasury under President Woodrow Wilson (1918-1920) before transitioning to Senator of Virginia (1920-1946). During his tenure as Senator, he would serve as President pro tempore (1941-1945). Throughout his career as a politician, he would serve as one of the defining factors of the modern federal financial institution, such as the implementation of the Glass-Owen Bill (1913), which established the Federal Reserve System.
The Carter Glass House was acquired in 1960 by the adjacent St. Pauls Church and converted into a parish house, where it is still in use today. It was added to the National Register of Historic Places in 1972.