The market opened in September of 1853 as farmers from all over the local area brought their meat and produce to sale. With it's convenient location near the B&O tracks, the Centre Market thrived and quickly expanded as shops and other businesses filled up the surrounding two blocks. This expansion brought in people of different ethnic origins such as Lebanese, Polish, Greek. A second market house designed by a prominent Wheeling architect, Edward B. Franzheim, and was completed in 1891 to meet the demands of the growing population.
Poor maintenance of the Centre Market over time led to the deterioration of some of the buildings. There were attempts made to save the buildings in both the 1960s and the 1970s, however they both failed. In 1982, Aetna Life, Casualty Foundation, and the City of Wheeling Came together with grant money to fully restore the Market Square. Some of the buildings could not be saved, and were rebuilt to mimic the originals, while over two thirds of the existing 58 buildings were originally constructed in the nineteenth century and have been restored and preserved. However, the entire district has retained its identity of preserving tradition. Today, the entire building remains open to the public as an open market, and houses a handful of restaurants, small eateries, a deli, unique shops, a local art gallery, and the famous Coleman's fish sandwich.