Like the park's other hotels, the Inn closed down during WW2. When it reopened in 1946, the park and Inn employees was not prepared for the large number of guests filling into the park. In 1959, the park was affected by the Hebgen Lake earthquake. The fireplaces of the dinning room and lobby of the Inn had to be rebuilt. Another near disaster struck again in 1988 with the North Fork Fire. The fire reached the steps of Inn, but with the valiant efforts of the firefighters, volunteers and the recently installed rooftop sprinkler system, the Inn was saved.
A huge celebration took place from 1993-1994 to celebrate the hotel's centennial. In 2004, the hotel was renovated and finally met with modern fire and safety standards. During the renovation, careful work was done to preserve the Inn's original work and design.
The 2014 Disney film, Planes: Fire and Rescue, takes place in a park influenced by Yellowstone, and a few others, and had an Inn that is reminiscent of the Old Faithful Inn. In the movie, the Inn was also threatened with a large fire and was saved by the characters who are fire fighters and the newly installed rooftop sprinkler system. The Inn was also featured in the 1935 film, Yellowstone, and a military-tech thriller novel, The Devil Colony, by James Rollins.